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pentobarbital boosts toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. CYP3A4 inducers could raise the metabolism of ifosfamide to its Lively alkylating metabolites.buprenorphine subdermal implant and pentobarbital equally improve sedation. Stay away from or Use Alternate Drug. Restrict use